Resources for Clinicians and Medical Professionals

Loeys-Dietz syndrome (LDS) is a genetic connective tissue disorder with multisystem involvement and variability in the type and severity of manifestations. It is best monitored and treated by a multidisciplinary team.

Head-to-Toe of Features Observed in Loeys-Dietz Syndrome

Features are described by body system, symptoms, diagnostic test, treatment, and more.

VASCERN Do’s and Don’ts for Situations Frequently Faced by Loeys-Dietz Syndrome Patients

Discusses pregnancy, delivery, and postpartum care, anaesthesia, aortic dissection, physical activity, retinal detachment, contraindicated medication, emergencies, allergies, and anaphylactic shock.

General Information on Loeys-Dietz Syndrome

Information on our website.

Article: Loeys-Dietz Syndrome (2018), by Dr. Bart Loeys and Dr. Harry Dietz

Discusses clinical characteristics, diagnosis and genetic counselling, management, activities and medication to avoid, risk for family members, and pregnancy.

Cardiovascular Risk Calculators

Indexes and calculators of aortic root z-score, vertebral tortuosity, patient outcomes, and more.

2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease

A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.
Guidelines for LDS imaging, medical therapy, surgical thresholds and considerations, pregnancy, cardiac rehabilitation, shared decision making, multidisciplinary teams, and more.

UTHealth Genomic Medicine Guidance Application

A point-of-care tool with clinical and genetic information on the following genes: TGFBR1, TGFBR2, TGFB2, SMAD3, ACTA2, PRKG1, MYLK, and MYH11.