{"id":1686,"date":"2022-07-18T16:52:13","date_gmt":"2022-07-18T20:52:13","guid":{"rendered":"https:\/\/loeysdietzcanada.org\/?page_id=1686"},"modified":"2024-08-15T12:58:22","modified_gmt":"2024-08-15T16:58:22","slug":"genetique","status":"publish","type":"page","link":"https:\/\/loeysdietzcanada.org\/fr\/syndrome-de-loeys-dietz\/genetique\/","title":{"rendered":"La g\u00e9n\u00e9tique"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1686\" class=\"elementor elementor-1686 elementor-695\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-696b9b95 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"696b9b95\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5c3b7916\" data-id=\"5c3b7916\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2317f12 elementor-widget elementor-widget-heading\" data-id=\"2317f12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">La g\u00e9n\u00e9tique\n<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-92f826f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"92f826f\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0292bde\" data-id=\"0292bde\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fcd32cc elementor-widget elementor-widget-text-editor\" data-id=\"fcd32cc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Le syndrome de Loeys-Dietz (SLD) est une <\/span><b>maladie g\u00e9n\u00e9tique<\/b><span style=\"font-weight: 400;\"> caus\u00e9e par une mutation (changement) dans les g\u00e8nes SMAD2, SMAD3, TGFB2, TGFB3, TGFBR1 ou TGFBR2.\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eb718ce elementor-widget elementor-widget-spacer\" data-id=\"eb718ce\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b6d04e elementor-widget elementor-widget-heading\" data-id=\"5b6d04e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Types du syndrome de Loeys-Dietz<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7f180be elementor-widget elementor-widget-spacer\" data-id=\"7f180be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad4bfb8 elementor-widget elementor-widget-text-editor\" data-id=\"ad4bfb8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Il existe six types du syndrome de Loeys-Dietz. <\/span><\/p><p><span style=\"font-weight: 400;\">Chacun est caus\u00e9 par des mutations dans un g\u00e8ne diff\u00e9rent :<\/span><\/p><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Le <strong>syndrome de Loeys-Dietz de type 1<\/strong> est caus\u00e9 par des mutations dans le <strong>g\u00e8ne TGFBR1<\/strong> (facteur de croissance transformant b\u00eata, r\u00e9cepteur de type 1).<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Le <strong>syndrome de Loeys-Dietz de type 2<\/strong> est caus\u00e9 par des mutations dans le <strong>g\u00e8ne TGFBR2<\/strong> (facteur de croissance transformant b\u00eata, r\u00e9cepteur de type 2).<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Le <strong>syndrome de Loeys-Dietz de type 3<\/strong> est caus\u00e9 par des mutations dans le <strong>g\u00e8ne SMAD3<\/strong> (m\u00e8res contre homologue d\u00e9capentapl\u00e9gique 3).<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Le <strong>syndrome de Loeys-Dietz de type 4<\/strong> est caus\u00e9 par des mutations dans le <strong>g\u00e8ne<\/strong> <strong>TGFB2<\/strong> (facteur de croissance transformant b\u00eata 2).<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Le <strong>syndrome de Loeys-Dietz de type 5<\/strong> est caus\u00e9 par des mutations dans le <strong>g\u00e8ne<\/strong> <strong>TGFB3<\/strong> (facteur de croissance transformant b\u00eata 3).<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Le <strong>syndrome de Loeys-Dietz de type 6<\/strong> est caus\u00e9 par des mutations dans le <strong>g\u00e8ne<\/strong> <strong>SMAD2<\/strong> (m\u00e8res contre homologue d\u00e9capentapl\u00e9gique 2).\u00a0\u00a0<\/span><\/li><\/ul><p><span style=\"font-weight: 400;\">Les chercheurs continuent d&#8217;explorer si et comment les types de SLD produisent des <a href=\"https:\/\/loeysdietzcanada.org\/fr\/signes-et-symptomes\/\" target=\"_blank\" rel=\"noopener\">manifestations physiques diff\u00e9rentes<\/a> <\/span><span style=\"font-weight: 400;\">ainsi que l&#8217;impact de ces similitudes et diff\u00e9rences sur les soins m\u00e9dicaux.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1e6d70e elementor-widget elementor-widget-spacer\" data-id=\"1e6d70e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-42d7d2e5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"42d7d2e5\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1bab084c\" data-id=\"1bab084c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-18db0650 elementor-widget elementor-widget-heading\" data-id=\"18db0650\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Les tests g\u00e9n\u00e9tiques peuvent confirmer un diagnostic<br> du syndrome de Loeys-Dietz.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-16add51e elementor-widget-mobile__width-inherit elementor-align-center elementor-widget elementor-widget-button\" data-id=\"16add51e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/loeysdietzcanada.org\/fr\/recevoir-diagnostic-syndrome-de-loeys-dietz\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-long-arrow-alt-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Recevoir un diagnostic <\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<script>\n\t\t\t\t(function($) {\n                    \"use strict\";\n\n                    var target = $('.elementor-element-42d7d2e5');\n                    target.addClass('e-lazyloaded');\n\n                    \n                    var EaelParallaxElement = {\n\n\t\t\t\t\t\tinit: function() {\n\t\t\t\t\t\t\telementorFrontend.hooks.addAction('frontend\/element_ready\/global', EaelParallaxElement.initWidget);\n\t\t\t\t\t\t},\n                        responsiveParallax: function(){\n                            var android = 0,\n                                ios = 0;\n                            switch( true || 1 ){\n                                case android && ios:\n                                    return \/iPad|iPhone|iPod|Android\/;\n                                    break;\n                                case android && ! ios:\n                                    return \/Android\/;\n                                    break;\n                                case ! android && ios:\n                                    return \/iPad|iPhone|iPod\/;\n                                    break;\n                                case ( ! android && ! ios ):\n                                    return null;\n                            }\n                        },\n\t\t\t\t\t\tinitWidget: function( $scope ) {\n\n\t\t\t\t\t\t\ttarget.jarallax({\n\t\t\t\t\t\t\t\ttype: 'scroll',\n\t\t\t\t\t\t\t\tspeed: 1.3,\n\t\t\t\t\t\t\t\tkeepImg: true,\n                                disableParallax: EaelParallaxElement.responsiveParallax(),\n\t\t\t\t\t\t\t});\n\t\t\t\t\t\t}\n\n\t\t\t\t\t};\n\n\t\t\t\t\t$( window ).on('elementor\/frontend\/init', EaelParallaxElement.init);\n\n                    \t\t\t\t}( jQuery ) );\n\t\t\t<\/script>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-4e9833c8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4e9833c8\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-93b4f5c\" data-id=\"93b4f5c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-75c238d6 elementor-widget__width-auto elementor-widget elementor-widget-heading\" data-id=\"75c238d6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Questions fr\u00e9quemment pos\u00e9es<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-242dbac1\" data-id=\"242dbac1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3d02e919 elementor-widget elementor-widget-eael-adv-accordion\" data-id=\"3d02e919\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-adv-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t            <div class=\"eael-adv-accordion\" id=\"eael-adv-accordion-3d02e919\" data-scroll-on-click=\"no\" data-scroll-speed=\"300\" data-accordion-id=\"3d02e919\" data-accordion-type=\"accordion\" data-toogle-speed=\"300\">\n            <div class=\"eael-accordion-list\">\n\t\t\t\t\t<div id=\"comment-les-mutations-causent-elles-le-sld\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"1\" aria-controls=\"elementor-tab-content-1021\"><span class=\"eael-advanced-accordion-icon-closed\"><\/span><span class=\"eael-advanced-accordion-icon-opened\"><\/span><span class=\"eael-accordion-tab-title\">Comment les mutations causent-elles le SLD?<\/span><i aria-hidden=\"true\" class=\"fa-toggle fas fa-plus\"><\/i><\/div><div id=\"elementor-tab-content-1021\" class=\"eael-accordion-content clearfix\" data-tab=\"1\" aria-labelledby=\"comment-les-mutations-causent-elles-le-sld\"><p><span style=\"font-weight: 400\">Les g\u00e8nes SMAD2, SMAD3, TGFB2, TGFB3, TGFBR1 et TGFBR2 contiennent chacun des instructions pour construire une prot\u00e9ine sp\u00e9cifique qui joue un r\u00f4le dans la <\/span><b>voie du TGF b\u00eata<\/b><span style=\"font-weight: 400\">. <\/span><\/p><p>\u00a0<\/p><p><span style=\"font-weight: 400\">Cette voie est une s\u00e9rie d&#8217;actions et d&#8217;interactions mol\u00e9culaires impliqu\u00e9es dans le d\u00e9veloppement, la croissance, la fonction immunitaire et le maintien des tissus de l&#8217;organisme.<\/span><\/p><p>\u00a0<\/p><p><span style=\"font-weight: 400\">Lorsqu&#8217;une <\/span><b>mutation causant le SLD<\/b><span style=\"font-weight: 400\"> se produit dans l&#8217;un de ces g\u00e8nes, le g\u00e8ne ne peut pas transmettre correctement ses instructions de construction de la prot\u00e9ine et donc cette prot\u00e9ine deviendra dysfonctionnelle. Ceci interf\u00e8re avec la fonction de la voie du TGF b\u00eata dans l&#8217;organisme et entra\u00eene finalement les signes et sympt\u00f4mes du SLD.<\/span><\/p><p>\u00a0<\/p><p><span style=\"font-weight: 400\">En savoir plus sur <a href=\"https:\/\/loeysdietzcanada.org\/fr\/la-genetique-et-le-syndrome-de-loeys-dietz\/\" target=\"_blank\" rel=\"noopener\">les g\u00e8nes, les mutations et la voie du TGF b\u00eata<\/a>.<\/span><span style=\"font-weight: 400\">\u00a0<\/span><\/p><\/div>\n\t\t\t\t\t<\/div><div class=\"eael-accordion-list\">\n\t\t\t\t\t<div id=\"do-viennent-les-mutations\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"2\" aria-controls=\"elementor-tab-content-1022\"><span class=\"eael-advanced-accordion-icon-closed\"><\/span><span class=\"eael-advanced-accordion-icon-opened\"><\/span><span class=\"eael-accordion-tab-title\">D'o\u00f9 viennent les mutations?<\/span><i aria-hidden=\"true\" class=\"fa-toggle fas fa-plus\"><\/i><\/div><div id=\"elementor-tab-content-1022\" class=\"eael-accordion-content clearfix\" data-tab=\"2\" aria-labelledby=\"do-viennent-les-mutations\"><p><span style=\"font-weight: 400\"><strong>Environ 75 % des personnes atteintes de SLD sont les premiers membres de leur famille \u00e0 \u00eatre atteints de cette maladie.<\/strong> Leur <\/span><b>mutation<\/b> <b><i>de novo<\/i><\/b><span style=\"font-weight: 400\"> (nouvelle) se produit au hasard dans la cellule reproductrice d&#8217;un parent (ovule ou sperme) ou pendant la conception ou l&#8217;embryogen\u00e8se (lorsque l&#8217;embryon se d\u00e9veloppe). Aucune cause parentale, telle que la prise de m\u00e9dicaments ou la consommation d&#8217;alcool, n&#8217;est \u00e0 l&#8217;origine de la mutation.<\/span><\/p><p>\u00a0<\/p><p><span style=\"font-weight: 400\"><strong>Environ 25 % des personnes atteintes de SLD ont un parent atteint de cette maladie.<\/strong> Leur mutation est transmise de parent \u00e0 enfant selon un <\/span><b>mod\u00e8le d&#8217;h\u00e9r\u00e9dit\u00e9<\/b><span style=\"font-weight: 400\"> dit <\/span><b>autosomique dominant<\/b><span style=\"font-weight: 400\">. &#8220;Autosomique&#8221; signifie que la mutation se trouve dans un g\u00e8ne situ\u00e9 sur un chromosome autosomique (une longue mol\u00e9cule compos\u00e9e d&#8217;ADN et de prot\u00e9ines <\/span><span style=\"font-weight: 400\">qui n\u2019intervient pas dans la determination du sexe de l\u2019enfant<\/span><span style=\"font-weight: 400\">). &#8220;Dominant&#8221; signifie qu&#8217;un enfant peut \u00eatre atteint du SLD apr\u00e8s avoir re\u00e7u une copie du g\u00e8ne mut\u00e9 d&#8217;un parent et une copie du g\u00e8ne normal de l&#8217;autre parent ; il suffit qu&#8217;il re\u00e7oive une copie du g\u00e8ne mut\u00e9 (et non deux) pour \u00eatre atteint du SLD. En raison du mode de transmission autosomique dominant, les personnes atteintes du SLD ont 50 % de chances de transmettre leur mutation g\u00e9n\u00e9tique \u00e0 chacun de leurs enfants. Cependant, il est impossible de pr\u00e9dire le degr\u00e9 de toute manifestation potentielle du SLD (vasculaire, squelettique, cutan\u00e9e ou autre) chez un enfant.<\/span><\/p><\/div>\n\t\t\t\t\t<\/div><div class=\"eael-accordion-list\">\n\t\t\t\t\t<div id=\"tests-gntiques-et-le-syndrome-de-loeys-dietz\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"3\" aria-controls=\"elementor-tab-content-1023\"><span class=\"eael-advanced-accordion-icon-closed\"><\/span><span class=\"eael-advanced-accordion-icon-opened\"><\/span><span class=\"eael-accordion-tab-title\">Tests g\u00e9n\u00e9tiques et le syndrome de Loeys-Dietz<\/span><i aria-hidden=\"true\" class=\"fa-toggle fas fa-plus\"><\/i><\/div><div id=\"elementor-tab-content-1023\" class=\"eael-accordion-content clearfix\" data-tab=\"3\" aria-labelledby=\"tests-gntiques-et-le-syndrome-de-loeys-dietz\"><p><span style=\"font-weight: 400\">Gr\u00e2ce aux <\/span><b>tests g\u00e9n\u00e9tiques<\/b><span style=\"font-weight: 400\">, un laboratoire est en mesure d&#8217;examiner l&#8217;information g\u00e9n\u00e9tique d&#8217;une personne et d&#8217;identifier les changements qui peuvent \u00eatre li\u00e9s \u00e0 des conditions m\u00e9dicales. <\/span><span style=\"font-weight: 400\">Le test peut confirmer un diagnostic de syndrome de Loeys-Dietz. <\/span><\/p><p>\u00a0<\/p><p><span style=\"font-weight: 400\">Apprenez-en davantage sur <a href=\"https:\/\/loeysdietzcanada.org\/fr\/syndrome-de-loeys-dietz\/recevoir-diagnostic-syndrome-de-loeys-dietz\/\" target=\"_blank\" rel=\"noopener\">les options de tests g\u00e9n\u00e9tiques, les r\u00e9sultats des tests et les professionnels qui peuvent vous aider.<\/a><\/span><\/p><\/div>\n\t\t\t\t\t<\/div><div class=\"eael-accordion-list\">\n\t\t\t\t\t<div id=\"risques-pour-la-famille\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"4\" aria-controls=\"elementor-tab-content-1024\"><span class=\"eael-advanced-accordion-icon-closed\"><\/span><span class=\"eael-advanced-accordion-icon-opened\"><\/span><span class=\"eael-accordion-tab-title\">Risques pour la famille<\/span><i aria-hidden=\"true\" class=\"fa-toggle fas fa-plus\"><\/i><\/div><div id=\"elementor-tab-content-1024\" class=\"eael-accordion-content clearfix\" data-tab=\"4\" aria-labelledby=\"risques-pour-la-famille\"><p><span style=\"font-weight: 400\">Lorsqu&#8217;une personne re\u00e7oit son diagnostic, cela peut soulever d&#8217;importantes questions g\u00e9n\u00e9tiques pour les membres de sa famille.<\/span><\/p><p>\u00a0<\/p><p><span style=\"font-weight: 400\">Pour les parents d&#8217;une personne atteinte de SLD :<\/span><span style=\"font-weight: 400\">\u00a0<\/span><\/p><ul><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Environ 25 % des personnes diagnostiqu\u00e9es de SLD ont un parent atteint de SLD.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Si la mutation \u00e0 l&#8217;origine du SLD de la personne est connue (par exemple, elle re\u00e7oit un r\u00e9sultat positif \u00e0 un test g\u00e9n\u00e9tique), il est recommand\u00e9 que les deux parents subissent un test g\u00e9n\u00e9tique pour la mutation.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Si la mutation de l&#8217;individu est inconnue, il est recommand\u00e9 de proc\u00e9der \u00e0 un examen clinique (physique) des deux parents.<\/span><\/li><\/ul><p>\u00a0<\/p><p><span style=\"font-weight: 400\">Pour les fr\u00e8res et s\u0153urs d&#8217;une personne atteinte de SLD :<\/span><span style=\"font-weight: 400\">\u00a0<\/span><\/p><ul><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Si le parent de la personne est atteint du SLD (cliniquement ou par le biais d&#8217;un test g\u00e9n\u00e9tique), il y a 50 % de chances que le fr\u00e8re ou la s\u0153ur de la personne ait h\u00e9rit\u00e9 de la mutation et de l&#8217;affection \u00e0 l&#8217;origine du SLD.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Si les parents de l&#8217;individu semblent cliniquement (physiquement) non affect\u00e9s et que les r\u00e9sultats des tests g\u00e9n\u00e9tiques sont n\u00e9gatifs, le risque pour les fr\u00e8res et s\u0153urs est faible. Cependant, ils sont toujours consid\u00e9r\u00e9s plus \u00e0 risque que le reste de la population, en raison de la possibilit\u00e9 de parents qui sont \u00e0 <\/span><b>p\u00e9n\u00e9trance r\u00e9duite<\/b><span style=\"font-weight: 400\"> (personnes atteintes d&#8217;un trouble g\u00e9n\u00e9tique qui n&#8217;expriment pas les manifestations de la maladie) ou du <\/span><b>mosa\u00efcisme<\/b><span style=\"font-weight: 400\"> (une condition o\u00f9, au lieu d&#8217;avoir toutes les cellules avec la m\u00eame g\u00e9n\u00e9tique, une personne aura deux ou plusieurs groupes de cellules g\u00e9n\u00e9tiquement diff\u00e9rentes).<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Une \u00e9valuation clinique et\/ou un test g\u00e9n\u00e9tique de la s\u0153ur ou du fr\u00e8re sont recommand\u00e9s.\u00a0\u00a0<\/span><\/li><\/ul><p>\u00a0<\/p><p><span style=\"font-weight: 400\">Pour les enfants d&#8217;une personne atteinte de SLD :<\/span><\/p><ul><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Il y a 50 % de chances que l&#8217;enfant ait h\u00e9rit\u00e9 la mutation \u00e0 l&#8217;origine du SLD et l&#8217;affection.<\/span><\/li><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Une \u00e9valuation clinique et\/ou un test g\u00e9n\u00e9tique de l&#8217;enfant sont recommand\u00e9s.<\/span><\/li><\/ul><p>\u00a0<\/p><p><span style=\"font-weight: 400\">Pour la famille \u00e9largie d&#8217;une personne atteinte de SLD :<\/span><\/p><ul><li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Le risque pour la famille \u00e9largie d\u00e9pend du lien de parent\u00e9 (parent, fr\u00e8re ou s\u0153ur, enfant) avec un autre membre de la famille atteint de SLD.<\/span><\/li><\/ul><p>\u00a0<\/p><p><span style=\"font-weight: 400\">Un examen clinique (physique) complet et\/ou un test g\u00e9n\u00e9tique sont importants pour le diagnostic d&#8217;une famille. La famille d&#8217;une personne peut \u00eatre atteinte du SLD mais ne pas sembler l&#8217;\u00eatre en raison d&#8217;un examen clinique incomplet, de sympt\u00f4mes apparaissant plus tard dans la vie, d&#8217;une p\u00e9n\u00e9trance r\u00e9duite ou d&#8217;un mosa\u00efcisme. Un sp\u00e9cialiste en g\u00e9n\u00e9tique peut aider \u00e0 expliquer ces possibilit\u00e9s, \u00e0 organiser un examen clinique approfondi et un test g\u00e9n\u00e9tique, et \u00e0 discuter des prochaines \u00e9tapes.<\/span><\/p><\/div>\n\t\t\t\t\t<\/div><div class=\"eael-accordion-list\">\n\t\t\t\t\t<div id=\"planification-familiale\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"5\" aria-controls=\"elementor-tab-content-1025\"><span class=\"eael-advanced-accordion-icon-closed\"><\/span><span class=\"eael-advanced-accordion-icon-opened\"><\/span><span class=\"eael-accordion-tab-title\">Planification familiale<\/span><i aria-hidden=\"true\" class=\"fa-toggle fas fa-plus\"><\/i><\/div><div id=\"elementor-tab-content-1025\" class=\"eael-accordion-content clearfix\" data-tab=\"5\" aria-labelledby=\"planification-familiale\"><p><span style=\"font-weight: 400\">Il est recommand\u00e9 que les personnes atteintes du SLD qui sont en \u00e2ge de procr\u00e9er et qui souhaitent avoir des enfants rencontrent un sp\u00e9cialiste en g\u00e9n\u00e9tique pour discuter du <\/span><b>risque de r\u00e9currence<\/b><span style=\"font-weight: 400\"> (la probabilit\u00e9 que des membres de la famille, comme la descendance, soient atteints du SLD).<\/span><\/p><p><span style=\"font-weight: 400\">Gr\u00e2ce aux progr\u00e8s des tests g\u00e9n\u00e9tiques, il existe d\u00e9sormais diverses <\/span><b>options de planification familiale pour le syndrome de Loeys-Dietz<\/b><span style=\"font-weight: 400\">. Si la mutation familiale est connue, un test SLD peut \u00eatre effectu\u00e9 avant et pendant la grossesse. Le test peut aider les personnes \u00e0 avoir un enfant sans syndrome de Loeys-Dietz ou \u00e0 recevoir un diagnostic pr\u00e9coce pour leur enfant. Un sp\u00e9cialiste peut discuter des pr\u00e9occupations m\u00e9dicales, personnelles et financi\u00e8res afin d&#8217;aider les familles \u00e0 choisir l&#8217;option qui leur convient le mieux.<\/span><\/p><p><span style=\"font-weight: 400\">Avant la grossesse, une <\/span><b>f\u00e9condation in vitro<\/b><span style=\"font-weight: 400\"> peut \u00eatre r\u00e9alis\u00e9e en laboratoire pour combiner un ovule et un spermatozo\u00efde pr\u00e9alablement collect\u00e9s en un embryon. L&#8217;embryon peut ensuite \u00eatre test\u00e9 pour le SLD par le biais d&#8217;un <\/span><b>test g\u00e9n\u00e9tique pr\u00e9implantatoire<\/b><span style=\"font-weight: 400\">. Les embryons non affect\u00e9s par le SLD peuvent \u00eatre implant\u00e9s chez la m\u00e8re ou la m\u00e8re porteuse.<\/span><\/p><p><span style=\"font-weight: 400\">Pendant la grossesse, les <\/span><b>tests pr\u00e9nataux<\/b><span style=\"font-weight: 400\"> peuvent aider \u00e0 d\u00e9terminer si la prog\u00e9niture est susceptible de pr\u00e9senter certaines anomalies cong\u00e9nitales ou conditions g\u00e9n\u00e9tiques. Pour le d\u00e9pistage du SLD, des options telles que le <\/span><b>pr\u00e9l\u00e8vement de villosit\u00e9s choriales<\/b> <b>(CVS)<\/b><span style=\"font-weight: 400\"> et <\/span><b>l&#8217;amniocent\u00e8se<\/b><span style=\"font-weight: 400\"> sont disponibles d\u00e8s la 10e semaine de grossesse. Les r\u00e9sultats des tests peuvent \u00eatre utilis\u00e9s pour l&#8217;interruption de la grossesse ou pour un diagnostic et un suivi pr\u00e9coces.<\/span><\/p><p class=\"p1\"><span class=\"s1\"><strong>Le livret sur la planification familiale avec le SLD<\/strong> est une ressource compl\u00e8te con\u00e7ue pour donner aux individus et aux familles les connaissances n\u00e9cessaires pour prendre des d\u00e9cisions \u00e9clair\u00e9es. Ce guide va au-del\u00e0 des informations fondamentales, abordant des aspects sp\u00e9cifiques li\u00e9s au syndrome de Loeys-Dietz et \u00e0 la planification familiale, \u00e0 la grossesse, \u00e0 l\u2019accouchement et aux soins post-partum.<\/span><\/p><p class=\"p3\"><span class=\"s1\"><a href=\"https:\/\/loeysdietzcanada.org\/wp-content\/uploads\/2023\/12\/FINAL-FR-COPY-LDS-Family-Planning.pdf\" target=\"_blank\" rel=\"noopener\">T\u00e9l\u00e9chargez cette ressource inestimable gratuitement ici.<\/a><\/span><\/p><\/div>\n\t\t\t\t\t<\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-31830a1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"31830a1\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1795679\" data-id=\"1795679\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-31afe74 elementor-widget elementor-widget-heading\" data-id=\"31afe74\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Avez-vous des questions sur la g\u00e9n\u00e9tique, le diagnostic <br>ou la suite des \u00e9v\u00e9nements pour votre famille ?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-51542f5 elementor-widget-mobile__width-inherit elementor-align-center elementor-widget elementor-widget-button\" data-id=\"51542f5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/loeysdietzcanada.org\/fr\/contactez-nous\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-long-arrow-alt-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contactez-nous<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<script>\n\t\t\t\t(function($) {\n                    \"use strict\";\n\n                    var target = $('.elementor-element-31830a1');\n                    target.addClass('e-lazyloaded');\n\n                    \n                    var EaelParallaxElement = {\n\n\t\t\t\t\t\tinit: function() {\n\t\t\t\t\t\t\telementorFrontend.hooks.addAction('frontend\/element_ready\/global', EaelParallaxElement.initWidget);\n\t\t\t\t\t\t},\n                        responsiveParallax: function(){\n                            var android = 0,\n                                ios = 0;\n                            switch( true || 1 ){\n                                case android && ios:\n                                    return \/iPad|iPhone|iPod|Android\/;\n                                    break;\n                                case android && ! ios:\n                                    return \/Android\/;\n                                    break;\n                                case ! android && ios:\n                                    return \/iPad|iPhone|iPod\/;\n                                    break;\n                                case ( ! android && ! ios ):\n                                    return null;\n                            }\n                        },\n\t\t\t\t\t\tinitWidget: function( $scope ) {\n\n\t\t\t\t\t\t\ttarget.jarallax({\n\t\t\t\t\t\t\t\ttype: 'scroll',\n\t\t\t\t\t\t\t\tspeed: 1.3,\n\t\t\t\t\t\t\t\tkeepImg: true,\n                                disableParallax: EaelParallaxElement.responsiveParallax(),\n\t\t\t\t\t\t\t});\n\t\t\t\t\t\t}\n\n\t\t\t\t\t};\n\n\t\t\t\t\t$( window ).on('elementor\/frontend\/init', EaelParallaxElement.init);\n\n                    \t\t\t\t}( jQuery ) );\n\t\t\t<\/script>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-b75d986 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b75d986\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-95ba3c0\" data-id=\"95ba3c0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-45ea954 elementor-widget elementor-widget-spacer\" data-id=\"45ea954\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ae06838 elementor-widget elementor-widget-eael-adv-accordion\" data-id=\"ae06838\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-adv-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t            <div class=\"eael-adv-accordion\" id=\"eael-adv-accordion-ae06838\" data-scroll-on-click=\"no\" data-scroll-speed=\"300\" data-accordion-id=\"ae06838\" data-accordion-type=\"accordion\" data-toogle-speed=\"300\">\n            <div class=\"eael-accordion-list\">\n\t\t\t\t\t<div id=\"rfrences\" class=\"elementor-tab-title eael-accordion-header\" tabindex=\"0\" data-tab=\"1\" aria-controls=\"elementor-tab-content-1821\"><span class=\"eael-advanced-accordion-icon-closed\"><\/span><span class=\"eael-advanced-accordion-icon-opened\"><\/span><span class=\"eael-accordion-tab-title\">R\u00e9f\u00e9rences<\/span><i aria-hidden=\"true\" class=\"fa-toggle fas fa-plus\"><\/i><\/div><div id=\"elementor-tab-content-1821\" class=\"eael-accordion-content clearfix\" data-tab=\"1\" aria-labelledby=\"rfrences\"><p><i><span style=\"font-weight: 400\">About Loeys-Dietz Syndrome<\/span><\/i><span style=\"font-weight: 400\">. Loeys-Dietz Syndrome Foundation. (n.d.). Retrieved October 11, 2022, from https:\/\/www.loeysdietz.org\/en\/medical-information\/#diagnosis\u00a0<\/span><\/p><p>\u00a0<\/p><p><span style=\"font-weight: 400\">Fabregat, I., &amp; Caballero-D\u00edaz, D. (2018). Transforming growth factor-\u03b2-induced cell plasticity in liver fibrosis and hepatocarcinogenesis. <\/span><i><span style=\"font-weight: 400\">Frontiers in Oncology<\/span><\/i><span style=\"font-weight: 400\">, <\/span><i><span style=\"font-weight: 400\">8<\/span><\/i><span style=\"font-weight: 400\">. https:\/\/doi.org\/10.3389\/fonc.2018.00357\u00a0<\/span><\/p><p>\u00a0<\/p><p><span style=\"font-weight: 400\">Findlay, J. K., Gear, M. L., Illingworth, P. J., Junk, S. M., Kay, G., Mackerras, A. H., Pope, A., Rothenfluh, H. S., &amp; Wilton, L. (2006). Human embryo: A biological definition. <\/span><i><span style=\"font-weight: 400\">Human Reproduction<\/span><\/i><span style=\"font-weight: 400\">, <\/span><i><span style=\"font-weight: 400\">22<\/span><\/i><span style=\"font-weight: 400\">(4), 905\u2013911. https:\/\/doi.org\/10.1093\/humrep\/del467\u00a0<\/span><\/p><p>\u00a0<\/p><p><span style=\"font-weight: 400\">Genetic Alliance; The New York-Mid-Atlantic Consortium for Genetic and Newborn Screening Services. Understanding Genetics: A New York, Mid-Atlantic Guide for Patients and Health Professionals. Washington (DC): Genetic Alliance; 2009 Jul 8. CHAPTER 1, GENETICS 101. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK115568\/<\/span><\/p><p>\u00a0<\/p><p><span style=\"font-weight: 400\">Kubiczkova, L., Sedlarikova, L., Hajek, R., &amp; Sevcikova, S. (2012). TGF-\u03b2 \u2013 an excellent servant but a bad master. <\/span><i><span style=\"font-weight: 400\">Journal of Translational Medicine<\/span><\/i><span style=\"font-weight: 400\">, <\/span><i><span style=\"font-weight: 400\">10<\/span><\/i><span style=\"font-weight: 400\">(1). https:\/\/doi.org\/10.1186\/1479-5876-10-183\u00a0<\/span><\/p><p>\u00a0<\/p><p><span style=\"font-weight: 400\">Loewe, L. (2008) Gen<\/span><span style=\"font-weight: 400\">etic mutation. <\/span><i><span style=\"font-weight: 400\">Nature Education<\/span><\/i><span style=\"font-weight: 400\"> 1(1):113<\/span><\/p><p>\u00a0<\/p><p><i><span style=\"font-weight: 400\">NCI Dictionary of Genetics terms<\/span><\/i><span style=\"font-weight: 400\">. National Cancer Institute. (n.d.). Retrieved October 11, 2022, from https:\/\/www.cancer.gov\/publications\/dictionaries\/genetics-dictionary\/def\/de-novo-mutation\u00a0<\/span><\/p><p>\u00a0<\/p><p><span style=\"font-weight: 400\">Public Health Agency of Canada. (2013, February 5). <\/span><i><span style=\"font-weight: 400\">Government of Canada<\/span><\/i><span style=\"font-weight: 400\">. Canada.ca. Retrieved October 11, 2022, from https:\/\/www.canada.ca\/en\/public-health\/services\/fertility\/genetic-testing-screening.html\u00a0<\/span><\/p><p>\u00a0<\/p><p><span style=\"font-weight: 400\">Shi, Y., &amp; Massagu\u00e9, J. (2003). Mechanisms of TGF-\u03b2 signaling from cell membrane to the nucleus. <\/span><i><span style=\"font-weight: 400\">Cell<\/span><\/i><span style=\"font-weight: 400\">, <\/span><i><span style=\"font-weight: 400\">113<\/span><\/i><span style=\"font-weight: 400\">(6), 685\u2013700. https:\/\/doi.org\/10.1016\/s0092-8674(03)00432-x\u00a0<\/span><\/p><p>\u00a0<\/p><p><span style=\"font-weight: 400\">U.S. National Library of Medicine. (n.d.). <\/span><i><span style=\"font-weight: 400\">Loeys-Dietz syndrome<\/span><\/i><span style=\"font-weight: 400\">. MedlinePlus. Retrieved October 11, 2022, from https:\/\/medlineplus.gov\/genetics\/condition\/loeys-dietz-syndrome\/\u00a0<\/span><\/p><p>\u00a0<\/p><p><span style=\"font-weight: 400\">Velchev, J. D., Van Laer, L., Luyckx, I., Dietz, H., &amp; Loeys, B. (2021). Loeys-Dietz Syndrome. <\/span><i><span style=\"font-weight: 400\">Advances in Experimental Medicine and Biology<\/span><\/i><span style=\"font-weight: 400\">, 251\u2013264. https:\/\/doi.org\/10.1007\/978-3-030-80614-9_11<\/span><\/p><\/div>\n\t\t\t\t\t<\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d5f6cc9 elementor-widget elementor-widget-spacer\" data-id=\"d5f6cc9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>La g\u00e9n\u00e9tique Le syndrome de Loeys-Dietz (SLD) est une maladie g\u00e9n\u00e9tique caus\u00e9e par une mutation (changement) dans les g\u00e8nes SMAD2, SMAD3, TGFB2, TGFB3, TGFBR1 ou TGFBR2.\u00a0 Types du syndrome de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":4444,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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